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Sunday sees the initial Wear-Tyne derby since 2024, but which side will celebrate – Sunderland or the Magpies?
"Throughout the majority of last season, no one would have predicted the Wearside club earning promotion and being competitive with Eddie Howe's Newcastle, let alone being above them in the table," commented analyst Chris Sutton.
"It is very different now, and the way they play convinces me they've got a genuine opportunity."
Sutton is making scoreline guesses for all 380 Premier League games this campaign, against artificial intelligence, readers and a assortment of guests.
For the upcoming matchday, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the eLions – the Football Association's formal esports team – at the football simulation European esports championship finals tournament, which is being held at Twickenham Stadium on Saturday.
The action will be streamed on Uefa's video platform, Instagram Live and TikTok channels, as well as the official Twitch channel and YouTube and the national team's Twitch.
Do you agree with their forecasts? Feel free to submit your own predictions below.
The most commonly selected scoreline picked for each game is displayed on the tables at the end of this page.
Predicting the right outcome (selecting a win, draw or defeat) is worth ten points. The exact score earns forty points.
Ray, who also plays Gen City and the Premier League champions as well as England, is entering the fray at the eEuros finals after getting through the qualifying.
The final eight competitors will represent their nations at the finals in a straight knockout, playing for a $100,000 prize pool and a highly sought-after spot in the FC Pro World Championship Play-Ins, with the Danish representative Anders Vejrgang defending the title he won last year.
"I'm feeling really good for it," Ray remarked. "I've got a really good coach by my side and training has been going well.
"It's always an honour to play for your country. Of course when you are younger, you imagine doing it as an actual footballer, but when you go into this field and there is an chance to represent England, putting the shirt on is something unique.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd not previously defeated him in a tournament before.
"I believe he is the number one in the world so getting a win over him in a tournament like this just provides a crazy boost of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The London club were impressive against the Gunners at the end of November, when they got a draw after going down to 10 men, and I was thinking they've turned a corner, they could possibly be title contenders.
In the matches following, however, they were beaten physically by Leeds, looked lethargic against Bournemouth and this week got beaten by Atalanta in the Champions League.
So head coach Enzo Maresca is in need of a win here to restore momentum, but it is a tough ask because the Toffees are such a threatening team.
Two of their stars are playing exceptionally and they have got a bit of a positive run at the moment.
Current evidence suggests you would probably back the visitors, while the most prudent prediction would probably be a draw, but I am not going to be sensible.
Chelsea haven't given me any compelling evidence to back them recently, but I just have a gut instinct Chelsea will win this match because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I am at this game and it will be interesting to see what we get from the Reds.
It was great to see for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the discussion with Mohamed Salah this week.
Slot ought not to put up with that drama. I know Salah has been a great for Liverpool but essentially Slot just wants to win games and there is no ulterior motive in his team selection.
They changed their shape against Inter and went with a midfield diamond formation and two up top.
The media is going to be talking about whether Salah is selected for this game, but the only way he is going to be brought back into the fold is if he makes amends.
Slot's primary concern will be on winning this game, but it is a challenging encounter.
You could argue it is the same for most teams but I find Brighton so hard to predict. I always feel they have got a goal in them, but they are quite open too.
Liverpool need to get back to winning consistently, but I am not sure how much their exertions at the San Siro will have taken out of them.
I have whacked a couple of Brighton players in my Fantasy Premier League side, so they will likely do poorly - but I do fancy them to get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the benefit of a free week while Newcastle had to exert themselves against Bayer Leverkusen on Wednesday, only to be pegged back late on.
With the exception of their superb performance against Everton a couple of weeks ago, Newcastle's away form has been poor, particularly straight after they've played in the Champions League.
It is anticipated that that tendency to continue on Sunday, and their tiredness is likely to be a factor in how this game goes because of their rivals' high press.
It was evident how relentless Regis le Bris's side are. They overpowered the Gunners, and it was a joy to watch.
Many pundits talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been brilliant, but Noah Sadiki, who plays next to him, has also been one of the top transfers and should be recognised too.
I am expecting this being the best game|most exciting fixture